"Drug Discovery Repurposing: Advances, Scopes and Opportunities" ed. by Mithun Rudrapal

This volume delivers up-to-date information on the identification of newer uses, molecular mechanisms, and novel targets of existing drug candidates through the application of various experimental, biophysical, and computational approaches and techniques. The book discusses recent advances in drug repurposing strategies that are currently being used in the discovery and development of drugs against difficult-to-treat, rare, and life-threatening diseases, including microbial infections, COVID-19, parasitic diseases, cardiovascular diseases, neurological disorders, and cancer. The book also discusses the modern experimental assays (HTS) and computational techniques including informatics and databases, molecular docking and dynamics, artificial intelligence and machine learning, virtual screening and pharmacophore modeling, proteomics and metabolomics, and network pharmacology and systems biology approaches.

Drug repurposing (or drug repositioning) is defined as the process of identifying new pharmacological indications of old, existing, investigational, or FDA-approved drugs for use in the treatment of diseases other than the drugs’ original intended therapeutic use. Some of the key features of the book are:
• Presents the strategies available for the development of drugs by drug repurposing approaches through various experimental and computational techniques for the treatment of difficult-to-treat, rare, and deadly diseases
• Summarizes the latest advances in the application of drug repurposing strategies, techniques, and approaches in the discovery and development of drugs
• Depicts drug development approaches from existing drug candidates and/or lead molecules through modern experimental assays, biophysical tools, and computational techniques
Written by a global team of experts, this book is useful for drug discovery scientists, drug developers, medicinal chemists, phytochemists, pharmacologists, clinicians, biochemists, biomedical scientists, healthcare professionals, researchers, teaching faculty, and students.

Contents
1. Role of Drug Repurposing in Cancer Treatment and Liposomal Approach of Drug Targeting
2. A Computational Approach for Identifying Experimental or Approved Drugs That Can Be Repurposed for the Treatment of Type-2 Diabetes
3. Targeted Modification of Physical-Chemical Properties of Drugs as a Universal Way to Transform “Old” Drugs into “New” Drugs
4. Recent Advancements in Phyto Component Based Nanocarriers for Improved Treatment of Brain Disorders
5. Utilizing 505(b)(2) Regulatory Pathway for New Drug Applications: An Overview on the Advanced Formulation Approach and Challenges
6. In Silico Drug Repurposing: An Effective Tool to Accelerate the Drug Discovery Process
7. Drug Repurposing: Challenges and Successes in the Treatment of SARS-CoV-2
8. Appraisal of Paclitaxel (Taxol) Pros and Cons in the Management of Cancer – Prospects in Drug Repurposing
9. Drug Repurposing: Scopes in Herbal/Natural Products-based Drug Discovery and Role of in silico Techniques
10. Computational Approaches in Drug Repurposing
11. Role of Drug Repurposing in Sustainable Drug Discovery
12. Development of Phytomedicines as Novel Antimalarial Lead Molecules: Progress towards Successful Antimalarial Drug Discovery
13. Effects and Pharmacological Use of Alkaloids on the Eyes


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