This book delves into the vital role of plants and their bioactive compounds in human health, emphasizing their medicinal and nutritional significance. It highlights the growing concern of drug resistance in anticancer and antimicrobial medications, compelling clinicians, and researchers worldwide to seek alternative solutions. Plants offer a diverse array of compounds, serving as a promising resource for novel and safe drug candidates and potentially enhancing drug efficacy while being easily metabolized in the human body. Their cost-effectiveness, safety profile, and minimal side effects make them an ideal source for developing new drug regimens. The book aims to attract students, teachers, and researchers across various disciplines, covering topics such as biochemistry, pharmacology, botany, medicinal chemistry, virology, nutrition, clinical biochemistry, and biomedicine. The book will explore the medicinal and nutritional importance of plants and their products, showcasing their applications in medicine, industries, cosmetics, therapeutics, and preventive measures.

Adrenoceptors have been at the forefront of physiological and pharmacological research for a century. They served as prototypes for rationale drug design as recognized by a Nobel Prize to Sir James Black and for the molecular understanding and structure of G protein-coupled receptors as recognized by a Nobel Prize to Brian Kobilka and Robert J. Lefkowitz. Drugs directly or indirectly targeting adrenoceptors have become guideline-recommended treatments for more than 30 human and various animal diseases. This volume assembles leading experts on various types of adrenoceptor research to provide concise insight into the current standing and future direction of uses of adrenoceptor-targeted drugs and research in this field.

This book explores the antifungal properties of natural products and reviews their antifungal mechanism. An introductory chapter illustrates the various fungal pathogenic species, common fungal diseases, and general mechanisms of action of various antifungal classes, including natural products. The book comprises seven sections and each section contains chapters on the efficacy and antifungal mode of action of plant extracts, essential oils, natural compounds, their derivatives, and plant-based nanoparticles. A section summarizes the antifungal efficacy of compounds derived from sources other than plants, like microbes. Besides compound toxicity, the book explores the antifungal mode of action and efficacy against the virulence and pathogenicity of fungal pathogens like Candida, Aspergillus, Cryptococcus, Histoplasma, and other pathogenic fungi. Further, the book also describes recent advancements in the discovery of novel drug targets and therapeutic strategies that are non-toxic and more efficacious for combating drug resistance. This book is an invaluable source for researchers working in the field of fungal biochemistry, anti-microbial, and anti-bacterial and undergraduate and postgraduate students of microbiology and pharmacology.

This book provides a comprehensive overview of plants and plant-derived phytochemicals in the management of cardiovascular diseases. It presents the cardioprotective potential of plants and phytochemicals, covering various preclinical models, assays, and clinical research protocols of plant medicine for cardioprotection. Chapters cover the role of plants and phytochemicals in prevention and cure of atherosclerosis, hypertension, cardiomyopathy, arrhythmia, myocardial ischemia, cardiotoxicity and the underlying pharmacological, molecular, biochemical, and immunobiological mechanisms. The book also includes toxicological aspects (safety evaluations), meta-analysis of clinical trials, critical assessments, drawbacks and challenges for adopting phytomedical approaches in evidence-based medicine for the treatment of CVDs. Screening methods and plant foods for cardioprotection are also covered.

To create this comprehensive resource, Dr. Neil Nathan assembled a team of leading medical experts to help you understand the source of your sensitivity and guide you to the best available treatment so you can feel, at long last, that you're on the path to reclaiming your life. Above all, this is a book of hope, especially for those who've been told that they just have to "live with it" and have had to isolate themselves from the world in order to survive. If you struggle with medical problems that have left you in this condition, Dr, Nathan and his teammates hope you'll join the thousands of patients they've helped to recover their health and rejoin their families and communities with a renewed sense of confidence and purpose.

“This book uses Caenorhabditis elegans as model animal to introduce the toxicity induction of toxicants at environmentally relevant concentrations under different conditions. It also discusses the systematic introduction of different molecular signaling pathways, as well as G protein coupled receptors and ion channels, in regulating the toxicity of toxicants at environmentally relevant concentrations.
The intestinal, neuronal, and germline molecular networks required for the regulation of toxicity of toxicants at environmentally relevant concentrations is further introduced and discussed. This book aims at providing a systematic understanding of the knowledge system on toxicology at environmentally relevant concentrations in Caenorhabditis elegans. ”

Although digenetic trematodes have been largely neglected, they constitute a major group of helminths that parasitize human and animals causing significant morbidity and mortality. This is of special importance today, since the geographical limits and the populations at risk, traditionally limited to developing or low-income countries, are currently expanding and changing in relation to factors such as growing international markets, improved transportation systems, and demographic changes. This has led to a growing international interest in trematode infections, although factors such as the difficulties entailed in the diagnosis, the complexity of human and agricultural practices, the lack of assessments of economic costs, or the limited number of effective drugs are preventing the development of control measures of these diseases in humans and livestock. In-depth studies are needed to clarify the current epidemiology of these helminth infections and to identify new and specific targets for both effective diagnosis and treatments. The main goal of the third edition of this book is to present the major trematodes and their corresponding diseases in the framework of modern parasitology, considering matters such as the application of novel techniques and analysis of data in the context of host-parasite interactions and also with the resident microbiota, showing the application of modern techniques and concepts to the studies on digenetic trematodes. This is an ideal book for parasitologists, microbiologists, zoologists, immunologists, public health professionals, clinicians and graduate and post-graduate students.

The book explores the intersection of nanotechnology and allergic airway diseases. With a focus on diagnosis and management, each chapter delves into specific areas of interest. Beginning with an introduction to the diseases, the book progresses to uncover the pathophysiology and immunology underlying allergic airway diseases. The epidemiology chapter provides insights into the prevalence and impact of these conditions. A significant portion of the book is dedicated to nanotechnology applications, with chapters on metal and metal oxide nanoparticles, nanomicelles, carbon nanotubes, liposomes, polymeric nanoparticles, solid lipid nanoparticles, dendrimers, nanofibers, and quantum dots. These chapters delve into the potential of these nanomaterials in managing allergic airway diseases, highlighting their unique properties, and promising therapeutic approaches. Finally, the book concludes with a chapter on future directions, exploring emerging trends and potential advancements in the field. This book will be a valuable resource for academics, caregivers, researchers, and industry professionals working in the field of airway allergic diseases. It includes translational and clinical researchers, under-graduates and postgraduates (Masters), PhDs, and post-doctoral researchers of various disciplines, including pharmaceutical sciences, biotechnology, immunology, and medical and health sciences.

This book will provide an important source of practical information on the history of toxicology, the ways in which pollutants reach model organisms used in toxicology, sampling methods for research, mechanisms of toxicity and responses of aquatic organisms to toxic agents, as well as the use of therapeutic agents in current approaches. Determining the importance of environmentally friendly substances on antioxidant defense is an obvious area of future research.

This book offers a comprehensive exploration of malaria, a life-threatening disease affecting millions globally, with a focus on the parasitic organisms of the genus Plasmodium that cause it. It discusses the challenges posed by the disease, especially in economically developing regions, and delves into the biology and pathophysiology of the Plasmodium species, including their genetic flexibility and resistance to treatments. Special attention is given to P. falciparum, the most dangerous of these parasites, detailing its complex life cycle, interaction with human hosts, and the severe clinical manifestations it can induce. The book further explores the global health concern of antimalarial drug resistance, highlighting the WHO's efforts in combating the disease and the necessity for novel treatments. Innovative research directions, such as targeting the unique organelles of Plasmodium like the apicoplast and employing proteasome inhibitors, are thoroughly examined as potential strategies in the development of new antimalarial drugs. Additionally, it addresses the critical role of the hemoglobin digestion process in the parasite's lifecycle, presenting it as a promising target for therapeutic intervention. This work is an essential resource for researchers, clinicians, and policymakers involved in malaria control and drug development, providing insights into the current challenges and future directions in the fight against this endemic disease.

The book gives an insight into the thorough study and examination of incumbent biosystems, their present status and disruption in their integrity, causes and effects, measures to be taken for their characterization and restoration apart from advances and applications in the field of biosciences, drug design, discovery, bio-systems, biomedical and drug delivery technologies, tools in particular. The book collates information from several disciplines, such as chemistry, biology, material science, engineering, statistics, biomedicine, genetics, etc., as the subject in question is a confluence of many disciplines exhibiting numerous applications such as bioimaging, novel biological agents, synthesis, discovery testing, characterization of drugs right from selecting a suitable precursor to discovering and designing a drug following a correct synthetic route, adoption of computer simulation-based models, AI/ML-based models, application of statistical tools in analyzing and interpreting data, design, multi-functional, and operational drug delivery systems, their bio-compatibility, capacity of carrying and release of drug reproducibly etc.