John E. Schiel, Darryl L. Davis, Oleg V. Borisov - State-of-the-Art and Emerging Technologies for Therapeutic Monoclonal Antibody Characterization. Volume 3: Defining the Next Generation of Analytical and Biophysical Techniques
Published: 2016-06-24 | ISBN: 0841230315 | PDF | 464 pages | 8.03 MB
This volume describes novel and emerging analytical technologies for analysis of proteins with the emphasis on technologies aimed to address characterization "knowledge gaps" and/or improve our ability to measure specified attributes with improved selectivity, sensitivity, resolution, and throughput.
Higher order structure of proteins is a recognized important attribute of mAbs, with potential implications on stability, safety, and biological function of these large molecules. This book, the last in a series of three volumes, touches on topics ranging from X-ray crystallography, NMR, hydrogen-deuterium exchange mass spectrometry, covalent labeling techniques, and ion mobility mass spectrometry.