Untranslated Gene Regions and Other Non-coding Elements: Regulation of Eukaryotic Gene Expression (repost)
Untranslated Gene Regions and Other Non-coding Elements: Regulation of Eukaryotic Gene Expression by Lucy W. Barrett, Sue Fletcher and Steve D. Wilton
English | 2013 | ISBN-10: 3034806787 | 80 pages | PDF | 2,2 MB
English | 2013 | ISBN-10: 3034806787 | 80 pages | PDF | 2,2 MB
There is now compelling evidence that the complexity of higher organisms correlates with the relative amount of non-coding RNA rather than the number of protein-coding genes.
Previously dismissed as “junk DNA”, it is the non-coding regions of the genome that are responsible for regulation, facilitating complex temporal and spatial gene expression through the combinatorial effect of numerous mechanisms and interactions working together to fine-tune gene expression.
The major regions involved in regulation of a particular gene are the 5’ and 3’ untranslated regions and introns. In addition, pervasive transcription of complex genomes produces a variety of non-coding transcripts that interact with these regions and contribute to regulation. This book discusses recent insights into the regulatory roles of the untranslated gene regions and non-coding RNAs in the control of complex gene expression, as well as the implications of this in terms of organism complexity and evolution.