Vitamin D in Chronic Kidney Disease

Editors: Urena Torres, Pablo A., Cozzolino, Mario, Vervloet, M. (Eds.)
This book will focus on vitamin D in Chronic Kidney Disease states Discusses recent insights on vitamin D metabolism as well as its association with a diversity of non-skeletal complications, among them cardiovascular disease, diabetes mellitus, multiple sclerosis, cancer, tuberculosis, and immune system dysfunction
New players in the regulation of vitamin synthesis and degradation have been identified and largely explored in case of CKD including FGF23 and klotho

Vitamin D deficiency, circulating levels lower than 15 ng/ml, is an epidemic disease worldwide with more than a billion people suffering of it in the beginning of the 21-century. Besides its impact on mineral and bone metabolism, these low vitamin D levels are also associated with a diversity of non-skeletal complications, among them cardiovascular disease, diabetes mellitus, multiple sclerosis, cancer, tuberculosis, and immune system dysfunction. Chronic Kidney Disease is also a very common disease, affecting more than 10% of the world population, ranging from stage 1 to stage 5 before dialysis. Approximately 1% of the population in industrialized countries is affected by end-stage renal disease (ESRD), needing a renal replacement therapy either hemodialysis or peritoneal dialysis, and ultimately by renal transplantation. Those CKD patients are more susceptible to exhibit reduced vitamin D stocks. Consequently, more than eighty percent of CKD patients have either insufficient or deficient vitamin D levels for multiple reasons.

Number of Illustrations and Tables
15 b/w illustrations, 51 illustrations in colour
Topics
Nephrology
Clinical Nutrition
Endocrinology



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