"RNA Interference" ed. by Ibrokhim Y. Abdurakhmonov

This book RNA interference provides an updated knowledge and progress on RNAi in various organisms, explaining basic principles, types, and property of inducers, structural modifications, delivery systems/methodologies, and various successful bench-to-field or clinic applications and disease therapies with some aspects of limitations, alternative tools, safety, and risk assessment.

RNA interference (RNAi), a hallmark of all biological sciences of twenty-first century, is an evolutionarily conserved and double-stranded RNA-dependent eukaryotic cell defense process. Opportunity to utilize an organisms own gene and to systematically induce and trigger RNAi for any desired sequence made RNAi an efficient approach for functional genomics, providing a solution for conventional longstanding obstacles in life sciences. RNAi research and application have significantly advanced during past two decades.


Contents
Preface
1 RNA Interference – A Hallmark of Cellular Function and Gene Manipulation
2 RNA Interference Technology — Applications and Limitations
3 The Role of Immune Modulatory MicroRNAs in Tumors
4 Long Noncoding RNAs are Frontier Breakthrough of RNA World and RNAi-based Gene Regulation
5 Noncanonical Synthetic RNAi Inducers
6 Microinjection-Based RNA Interference Method in the Water Flea, Daphnia pulex and Daphnia magna
7 ER-targeted Intrabodies Mediating Specific In Vivo Knockdown of Transitory Proteins in Comparison to RNAi
8 RNAi Therapeutic Potentials and Prospects in CNS Disease
9 RNAi-based Gene Therapy for Blood Genetic Diseases
10 Non-viral siRNA and shRNA Delivery Systems in Cancer Therapy
11 siRNA-Induced RNAi Therapy in Acute Kidney Injury
12 Preclinical Development of RNAi-Inducing Oligonucleotide Therapeutics for Eye Diseases
13 RNAi-Induced Immunity
14 Perspectives on RNA Interference in Immunopharmacology and Immunotherapy
15 RNA Interference as a Tool to Reduce the Risk of Rejection in Cell-Based Therapies
16 Utility of Potent Anti-viral MicroRNAs in Emerging Infectious Diseases
17 RNAi — Implications in Entomological Research and Pest Control
18 Management of Insect Pest by RNAi — A New Tool for Crop Protection
19 RNA Interference – Natural Gene-Based Technology for Highly Specific Pest Control (HiSPeC)
20 RNA Interference – A Powerful Functional Analysis Tool for Studying Tick Biology and its Control