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Molecular Mechanisms of Cell Differentiation in Gonad Development

Posted By: Underaglassmoon
Molecular Mechanisms of Cell Differentiation in Gonad Development

Molecular Mechanisms of Cell Differentiation in Gonad Development
Springer | Life Sciences | July 16, 2016 | ISBN-10: 331931971X | 428 pages | pdf | 7.81 mb

Editors: Piprek, Rafal P. (Ed.)
Provides a comprehensive overview of the early development of the gonads
Includes a particular focus on the mouse
Offers detailed reviews written by international experts


This book presents the current state of knowledge on the origin and differentiation of cell lines involved in the development of the vertebrate male and female gonads with particular emphasis on the mouse. It also discusses the processes leading to the testis- and ovary-specific structures and functions.
The individual chapters review the origin and differentiation of the somatic cells of the genital ridges; the formation and migration of primordial germ cells in mouse and man; the gonadal supporting cell lineage and mammalian sex determination; differentiation of Sertoli and granulosa cells; mesonephric cell migration into the gonads and vascularization; origin and differentiation of androgen-producing cells in the gonads; germ cell commitment to the oogenic versus spermatogenic pathway and the role of retinoic acid; ovarian folliculogenesis; control of oocyte growth and development by intercellular communication within the follicular niche; biology of the Sertoli cell in the fetal, pubertal and adult mammalian testis; mechanisms regulating spermatogonial differentiation; stem cells in mammalian gonads; the role of microRNAs in cell differentiation during gonad development; human sex development and its disorders; as well as methods for the study of gonadal development.

Number of Illustrations and Tables
4 b/w illustrations, 48 illustrations in colour
Topics
Developmental Biology
Stem Cells
Cytogenetics
Molecular Medicine
Reproductive Medicine

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