Interleukin 12: Antitumor Activity and Immunotherapeutic Potential in Oncology
Interleukin 12: Antitumor Activity and Immunotherapeutic Potential in Oncology
Springer | Immunology | October 25, 2016 | ISBN-10: 3319469053 | 75 pages | pdf | 1.25 mb
Springer | Immunology | October 25, 2016 | ISBN-10: 3319469053 | 75 pages | pdf | 1.25 mb
Authors: Lasek, Witold, Zagozdzon, Radoslaw
Explores the biology of interleukin 12 and its potential in cancer therapy
Discusses antitumor effects identified in preclinical studies and clinical trials in cancer immunotherapy
Is particularly relevant for scientists working in the pharmaceutical industry and in clinical oncology
This book discusses the immunotherapeutic potential of Interleukin 12 in the context of clinical oncology, as well as antitumor effects confirmed in preclinical studies and clinical trials in cancer immunotherapy. Due to its ability to activate both innate (NK cells) and adaptive (cytotoxic T lymphocytes) immunities, Interleukin 12 (IL-12) has been regarded as a promising candidate for tumor immunotherapy. However, despite the encouraging results in animal models, only very modest antitumor effects have been confirmed in early clinical trials. Recently, several clinical studies have been initiated in which IL-12 was applied as an adjuvant in cancer vaccines, in gene therapy including locoregional injections of IL-12 plasmid, and in the form of tumor-targeting immunocytokines (IL-12 fused to monoclonal antibodies).
Number of Pages
VII, 75
Number of Illustrations and Tables
6 b/w illustrations
Topics
Immunology
Cancer Research
Cytokines and Growth Factors
Oncology
Cell Biology
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