"Exploring New Findings on Amyloidosis" ed. by Ana-Maria Fernandez-Escamilla

This book opens an exciting door to provide up-to-date information about the function and the mechanisms of the amyloid formation process from the structural, biophysical, biomedical, and nanotechnological perspective, combining the new findings on toxic and functional amyloids studies using theoretical and experimental approaches to fight against amyloid-based diseases.

Amyloid protein aggregates are involved in 'protein-misfolding diseases' of enormous social and economic impact, still with no effective therapies. The most prevalent amyloid pathologies are related to neurodegenerative diseases, but amyloidosis also affects other organs. The majority of the studies includes serious health connotations on amyloids. However, not all amyloid fibers play a detrimental role in host. An increasing number of studies shows an important beneficial role as 'functional amyloids'.

Contents
Preface
1 Modulating Role of TTR in Aβ Toxicity, from Health to Disease
2 Supramolecular Organization of Amyloid Fibrils
3 Advances in AFM Imaging Applications for Characterizing the Biophysical Properties of Amyloid Fibrils
4 Effects of Amyloid-β Deposition on Mitochondrial Complex I Activity in Brain: A PET Study in Monkeys
5 Kinetics of Amyloid Formation by Different Proteins and Peptides: Polymorphism and Sizes of Folding Nuclei of Fibrils
6 Role of Glycation in Amyloid: Effect on the Aggregation Process and Cytotoxicity
7 Is Alzheimer's Associated Amyloid Beta an Innate Immune Protein
8 Amyloidogenesis and Responses to Stress
9 Developments in the Treatment of Amyloid A Amyloidosis Secondary to Rheumatoid Arthritis
10 The Role of Human IAPP in Stress and Inflammatory Processes in Type 2 Diabetes
11 Proteasome Inhibitors to Treat AL Amyloidosis