"Alzheimer's Disease: Challenges for the Future" ed. by Inga Zerr

There is a wide scope of clinical phenomenology in Alzheimers disease (AD), regarding the age of onset, presenting features, rate of progression and appearance of other clinical manifestation. Although clinical appearance and neuropathological hallmarks have been defining AD since its first description, major factors which trigger pathology are still unknown. The role of comorbidity is discussed controversially.

Important environmental risk factors in AD development are continuous stress, low education and cardiovascular risk factors such as alcohol intake, smoking, hypertension.
The role of lipids and cholesterol has been recognized, but the relevant pathogenetic steps are still to be identified.
There is an urgent need to understand molecular disease pathogenesis in order to develop early therapeutic targets for the disease.

Contents
Preface
1 Epidemiology of Alzheimer's Disease with the Projection of Falls Among the Aged Population
2 The Cascade of Oxidative Stress and Tau Protein Autophagic Dysfunction in Alzheimer’s Disease
3 Neuroinflammation and Alteration of the Blood-Brain Barrier in Alzheimer´s Disease
4 Metals Involvement in Alzheimer’s Disease — A Patho-Genetic View
5 Lipids and Lipoproteins in Alzheimer’s Disease
6 Free Cholesterol — A Double-Edge Sword in Alzheimer Disease
7 The Mevalonate Pathway in Alzheimer’s Disease — Cholesterol and Non-Sterol Isoprenoids
8 Recent Progress in the Identification of Non-Invasive Biomarkers to Support the Diagnosis of Alzheimer’s Disease in Clinical Practice and to Assist Human Clinical Trials
9 New Frontiers in Alzheimer's Disease Diagnosis
10 Genetic, Biochemical and Histopathological Aspects of Familiar Alzheimer's Disease
11 Gait Pathway in Subcortical Vascular Dementia and in Alzheimer’s Disease
12 The Alzheimer’s Patient in the Emergency Department — Specificities of Care
13 Uncontrolled Sexual Behaviour in Dementia