The Theory of Response-Adaptive Randomization in Clinical Trials by William F. Rosenberger
The Theory of Response-Adaptive Randomization in Clinical Trials by William F. Rosenberger
English | Aug 18, 2006 | ISBN: 0471653969 | 234 Pages | PDF | 8 MB
English | Aug 18, 2006 | ISBN: 0471653969 | 234 Pages | PDF | 8 MB
Presents a firm mathematical basis for the use of response-adaptive randomization procedures in practice The Theory of Response-Adaptive Randomization in Clinical Trials is the result of the authors' ten-year collaboration as well as their collaborations with other researchers in investigating the important questions regarding response-adaptive randomization in a rigorous mathematical framework. Response-adaptive allocation has a long history in biostatistics literature; however, largely due to the disastrous ECMO trial in the early 1980s, there is a general reluctance to use these procedures. This timely book represents a mathematically rigorous subdiscipline of experimental design involving randomization and answers fundamental question.