Structure-Based Design of Drugs and Other Bioactive Molecules: Tools and Strategies
Arun K. Ghosh, Sandra Gemma, "Structure-Based Design of Drugs and Other Bioactive Molecules: Tools and Strategies"
English | ISBN: 3527333657 | 2014 | 474 pages | PDF | 8 MB
English | ISBN: 3527333657 | 2014 | 474 pages | PDF | 8 MB
In contrast to previous texts focusing on either computational, structural or synthetic methods, this one–of–a–kind guide integrates all three skill sets for a complete picture of contemporary structure–based design. As a result, this practical book demonstrates how to develop a high–affinity ligand with drug–like properties for any given drug target for which a high–resolution structure exists. The authors, both of whom have successfully designed drug–like molecules that were later developed into marketed drugs, use numerous examples of recently developed drugs to present best practice in structure–based drug design with the novice in mind. By way of a carefully balanced mix of theoretical background and case studies from medicinal chemistry applications, readers will quickly and efficiently master the basic skills of successful drug design.