Defects in T Cell Trafficking and Resistance to Cancer Immunotherapy
Defects in T Cell Trafficking and Resistance to Cancer Immunotherapy (Resistance to Targeted Anti-Cancer Therapeutics, Book 9) by Emmanuel Donnadieu
English | 2016 | ISBN: 3319422219 | 199 pages | PDF | 6,6 MB
English | 2016 | ISBN: 3319422219 | 199 pages | PDF | 6,6 MB
This volume focuses on recent advances in understanding T cells as key players in antitumor immune responses, and as a result T cell-based immunotherapy is starting to transform the treatment of advanced cancers. However, despite recent successes, many patients with cancer fail to respond to these treatments. Defective migration of T cells into and within tumors is considered as an important resistance mechanism to cancer immunotherapy.
The volume includes three sections. The first section covers general knowledge about T cell trafficking during a normal immune response but also during tumor development. The second section provides an in-depth description of the different obstacles that prevent T cells from migrating and contacting tumor cells. The third section explores therapeutic strategies to improve trafficking of T cells into tumors and, thus, to enhance the effectiveness of cancer immunotherapy.