Phosphoinositide 3-kinase in Health and Disease: Volume 1
Christian Rommel, Bart Vanhaesebroeck, Peter K. Vogt - Phosphoinositide 3-kinase in Health and Disease: Volume 1
Published: 2010-09-30 | ISBN: 3642136621 | PDF | 310 pages | 4.47 MB
From humble beginnings over 25 years ago as a lipid kinase activity associated with certain oncoproteins, PI3K (phosphoinositide 3-kinase) has been catapulted to the forefront of drug development in cancer, immunity and thrombosis, with the first clinical trials of PI3K pathway inhibitors now in progress. Here we give a brief overview of some key discoveries in the PI3K area and their impact, and include thoughts on the current state of the field, and where it could go from here